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Local Daily News 20th November

The latest technology allows multiplying by 200 the genes that are analysed to treat cancer

Refine to the maximum in the diagnosis of cancer to design each customised treatment. The latest technology for addressing this disease allows the genes that are analysed to be multiplied by 200, thanks to massive DNA sequencing. A procedure that is carried out in the Pathological Anatomy laboratories of the Doctor Balmis General Hospital in Alicante, a reference centre in the province in the use of this technique, which has just incorporated a panel of genes for paediatric patients. What 10 years ago was research is now healthcare thanks to the study of genomic alterations for a personalised response to the patient.

Thanks to massive sequencing studies carried out on new-generation equipment for the detection of complex genetic alterations, more than 1,500 cancer patients have already obtained a more accurate interpretation of their tumour, almost half of them affected by breast cancer. lung but also colorectal or breast, central nervous system or biliary.

This technology allows hundreds of genes to be studied simultaneously, which simplifies and speeds up the process; and it means having in the portfolio of services of the Hospital of Alicante a technique that is complementary to the traditional ones, such as immunohistochemistry or PCR, which continue to be performed, although they used up more time and tissue. Massive sequencing gives very precise photos of the genetics of the tumour to refine the drugs that may work, identify certain mutations for which there are no medicines or even offer clinical trials to patients with no therapeutic alternative.

Likewise, a complete diagnosis is achieved without the need to outsource it to other hospitals, as has been done to date. This technique is also used in microbiology, haematology, clinical analysis, and as a research technique.

“The use of the latest technology in the field of genomic characterization is allowing us to advance in so-called precision medicine, which means offering a greater number of therapeutic options to patients, depending on the type of tumour and the genetic alterations they present. All this with the aim of increasing the survival of cancer patients”, explains Dr. Ignacio Aranda, head of the Pathological Anatomy Service for the last 25 years, who has just retired with the satisfaction of having modernised this department in collaboration with a group of about 40 professionals.

This technique allows the sequencing of millions of DNA and RNA fragments, making it capable of determining gene alterations with greater reliability and speed, reducing analysis time as well as costs. Allows you to see the molecular profile. Many different tumours have the same molecular alteration.

“One of the objectives of Pathological Anatomy is oncological diagnosis and, using this technology, in a period of between five and ten days, approximately, it is possible to have reliable results on each tumour that we examine. The incorporation of this technology would not have been possible without the involvement and commitment of highly qualified Pathology Anatomy technicians”, points out the new head of the service, Dr. Cristina Alenda.

In a single reaction between 160 and 200 genes can be studied, therefore it replaces the old techniques based on the study of a single gene. The increase in the number of genes under study makes it possible to detect genetic alterations that would not otherwise be found, increasing the prognostic and therapeutic possibilities for those patients with infrequent alterations. Determinant information so that the professionals of the Medical Oncology Service can design an individualised therapeutic strategy for each patient.

The system includes software that searches open clinical trials, both national and international, for specific markers, increasing the options for certain alterations.

Hospitals are looking for the most automated technology possible, which gives security to handle thousands of biopsies and allows a good response time since society demands more and more speed so that the patient does not perceive delays in the diagnosis.

Doctors consider it essential that this technology be accessible to all hospitals. To guarantee coverage to the entire population of the province and decentralise the diagnosis, the technique has been incorporated into the Elche Hospital.

The Consell and the Government agree to a reduction in the ecological flow that will allow the transfer to be maintained until 2026

The President of the Generalitat, Ximo Puig, has reached an agreement with the Vice President and Minister of Ecological Transition, Teresa Ribera, to increase the ecological flow of the Tagus by just 1 cubic metre per second as of January 1st, leaving it at 7 cubic metres per second. This measure will be in force until January 1, 2026, when the flow will increase to 7.5 cubic metres per second and in 2027 to 8.5 cubic metres per second. The great novelty of the agreement that must be ratified by the national water council on November 29 is that a clause is included in the Tagus hydrological plan by which the increases from 2026 would be determined based on whether the conditions are met environmental conditions set for the river. In this way, the increase that the Consell had proposed to determine the new conditions of the Tagus-Segura transfer is fulfilled. Sources from the Consell assure that the news has been well received by the Central Union of Irrigators of the Tagus-Segura.

Lucas Jiménez, president of the Central Union of Irrigators of the Tajo-Segura, has received the news with hope and above all with the confidence that the Government will do its homework over the next three years and the problem of poor purification in Madrid will be solved. which is the cause of the contamination of the Tagus River and not the transfer of water to Alicante and Murcia. Jiménez stresses that “this success, if it can be called that, although some prudence must be exercised, is due both to the work of the Consell of the Valencian Community and the government of Murcia, the Alicante Provincial Council, and, of course, all the work What we irrigators have been doing with our tractor units, protests and our studies that have shown that the flow of the Tagus should not even be touched. We are facing a step forward but let no one forget that the ecological flow is raised to 7 cubic metres per second. What is desirable, I insist, is that homework be done in Madrid and within three years, when we are going to decide again on ecological flows, pollution has been reduced and there is no need to touch them again”.

The future operating conditions of the Tagus-Segura transfer introduce a corrective mechanism, accompanied by a series of investments, which affects the criteria relating to the establishment of ecological flows and which should serve to guarantee the arrival of water to Alicante irrigation.

The Generalitat considers the modification that has been made with respect to the initial plans that were presented to the extent that the establishment of this mechanism lays the necessary foundations for the future maintenance of the transfer to be an important advance.

The Consell gives the green light to PLD Space to install its aeronautical centre in the IFA environment

The Elche space rocket company Payload Aerospace (PLD Space) already has the green light from the Consell to build its aeronautical centre in the vicinity of the Alicante Fair Institution (IFA). The Generalitat approved this Friday the agreement declaring a territorial project (PTE) for industries with a high technological and innovative component, the initiative presented by the company Payload Aerospace (PLD Space) in Elche.

The firm foresees an investment for the development of its products of up to 81 million euros until 2025 and generate 325 direct jobs, of which 90% will be highly qualified in technology, science and engineering (STEM).

The agreement, reached this Friday by the plenary session of the Consell, declares the Elche City Council as the public administration in charge of processing and approving the urban planning instruments necessary for the definitive implementation of the project.

The investment in the building and development project amounts to 34 million euros, apart from investments in fixed capital or other investments in technological equipment. In principle, the direct, indirect and induced effects of this investment would amount to around 72 million euros.

Regarding the impact on state, regional and local treasuries, the company has made scalable estimates based on the gradual incorporation of employees, the minimum being 3.2 million euros in 2022, and 11.9 million euros. euros in 2030. The Elche aeronautical firm is interested in occupying 50,000 metres on the IFA land. The regional Executive must inject around seven million euros to complete the urbanisation works of the land, in addition to solving some administrative procedures.

The Generalitat has explained that, to carry out this function, the company will be able to count on the help of the competent departments in matters of territorial and industry policy which, together with the Elche City Council, will be the public administrations in charge of monitoring the project.

The Consell maintains that this urban instrument “will also facilitate the implementation of companies of high technological and innovative value to consolidate the Valencian Community as a pole of attraction for talent and high employment”.

The activity to be carried out is related to space aeronautical construction and its machinery, and will contribute to the establishment in the Valencian Community of high-impact industrial sectors.

According to the promoter, the direct employment that will be generated will be 325 positions, of which 90% will be highly qualified in technology, science and engineering (STEM).

The installation of this company in Elche will provide greater visibility and positioning of the Community in the aeronautical space sector with strong growth on an international scale.

With this measure, the Consell takes a giant step in its commitment to the aerospace sector, which would have as its greatest exponent the fact that Elche managed to rise as the headquarters of the Spanish Space Agency. A candidacy that the Generalitat Valenciana will even present next Tuesday in Madrid to demonstrate its strength and the support of the entire Community for the project.

The firm plans to launch its first rocket, the Miura 1, at the end of this year, with which they will test their technology and, if everything goes according to plan, it will be in mid-2024 when they will put the Miura 5 into orbit, with which they will carry out your commercial activity. It is a 30-metre aircraft, so, although they can start some processes in the facilities they already have in Elche Parque Empresarial, they urgently need to already have a larger spacecraft in which to build the rockets.

Likewise, the company, based in Elche, will be able to promote the creation and consolidation of an aeronautical cluster and consolidate an innovative ecosystem in the Community, which already has important initiatives in industries with a high technological component and generate induced demand in the tourism sectors, hotels, restaurants due to the high mobility of professionals in the sector.

PLD Space is the Spanish company that leads the space launch business for small satellites in Europe and has a presence on the technology campus of the business park and a concession at Teruel Airport for its propellant test bench.

The General Hospital of Elche attends serious heart attacks from Monday 24 hours a day and avoids their transfer to Alicante

People who suffer an acute heart attack in the south of the province will no longer be transferred to Alicante, with the risk to their health that the distant distance sometimes entails, and they will be taken to the nearest General University Hospital of Elche, whatever time the emergency occurs.

This Monday the hemodynamics unit of the Elche hospital begins to function 24 hours a day. In this way, cardiac emergencies will be attended with more guarantees.

After years of demands, the General Hospital will offer this full-time assistance 365 days a year and not just seven hours a day, as the Minister of Health, Miguel Mínguez, promised a few months ago with the hospital manager, Carlos Gosálvez, and with the mayor of Elche, Carlos González.

To date, this comprehensive care was only available at the General Hospital of Alicante, so from this implementation it will be possible to avoid the transfer of around thirty patients per month, according to the calculations of the hospital.

The Hemodynamics Unit, attached to the Cardiology Service of the General Hospital of Elche, thus extends care to patients who suffer an acute myocardial infarction 24 hours a day, 365 days a year, becoming part, together with other hospitals of the Valencian Community in the care of the “Infarct Code”.

Until now, the unit cared for its patients on weekdays from 8 a.m. to 3 p.m. and, outside of those hours, they were referred to the reference hospital, the General de Alicante.

This extension of hours thus responds to the demand on the part of citizens who, in this way, see an increase in their quality of care. In addition, the General Hospital of Elche becomes a reference in the south of the province, since it will provide the service to the health departments of Vega Baja, both Orihuela and Torrevieja (outside Monday morning and afternoon hours). to Friday that serves these two departments) and Vinalopó.

The hemodynamics unit cares for more than 700 patients annually, a figure that will increase from now on. This has been possible thanks to the expansion of the staff carried out by the Ministry of Health with the increase in the number of cardiologists with expertise in hemodynamics, nurses and auxiliary nursing care technicians who work in said service.

In addition, last year, Health invested one million euros in improving the unit, providing it with state-of-the-art equipment, which represented a significant qualitative leap in this technique. In addition, the aesthetic adaptation of the room to house the new team was also carried out.



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